Contents

1 The Secrets of Life:1
A Mathematician's Introduction to Molecular Biology
Eric S. Lander and Michael S. Waterman
2 Mapping Heredity:25
Using Probabilistic Models and Algorithms to Map Genes and Genomes
Eric S. Lander
3 Seeing Conserved Signals:36
Using Algorithms to Detect Similarities Between Biosequences
Eugene W. Myers
4 Hearing Distant Echoes:90
Using Extremal Statistics to Probe Evolutionary Origins
Michael S. Waterman
5 Calibrating the Clock:114
Using Stochastic Processes to Measure the Rate of Evolution
Simon Tavaré
6 Winding the Double Helix:153
Using Geometry, Topology, and Mechanics of DNA
James H. White
7 Unwinding the Double Helix:179
Using Differential Mechanics to Probe Conformational Changes in DNA
Craig J. Benham
8 Lifting the Curtain:202
Using Topology to Probe the Hidden Action of Enzymes
DeWitt Sumners
9 Folding the Sheets:236
Using Computational Methods to Predict the Structure of Proteins
Fred E. Cohen
Appendix: Chapter Authors272
Index277

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http://www-hto.usc.edu/books/msw/msg/toc.html, webmaster@hto.usc.edu, 30 August 1996